Effect of antisense oligodeoxynucleotide of telomerase RNA on telomerase activity and cell apoptosis in human colon cancer

Table 1 Inhibitory effect of telomerase activity by ODNs (mean ± SD)

Groups	Active duration
	24 h	48 h	72 h	96 h	120 h
As-ODN 10 μmol/L	0.872 ± 0.194	0.406 ± 0.232	0.386 ± 0.146	0.307 ± 0.203	0.289 ± 0.213
Ms-ODN 10 μmol/L	1.063 ± 0.249	1.285 ± 0.179	0.959 ± 0.273	0.109 ± 0.243	1.247 ± 0.178
Positive control	1.725 ± 0.267	1.571 ± 0.418	1.243 ± 0.186	1.236 ± 0.235	1.098 ± 0.347
Negative control	0.349 ± 0.092	0.312 ± 0.076	0.283 ± 0.089	0.063 ± 0.072	0.057 ± 0.023

Table 2 Effect of ODNs on induction of SW480 cell apoptosis (mean ± SD)

Groups	Active duration
	48 h	72 h	96 h
As-ODN 1 μmol/L	4.99 ± 0.54	8.63 ± 0.59	9.96 ± 0.41
Ms-ODN 1 μmol/L	3.86 ± 0.39	4.88 ± 0.57	4.92 ± 0.67
HRT blank	1.57 ± 0.18	1.79 ± 0.21	1.71 ± 0.32