Esophageal Cancer
Copyright ©The Author(s) 2004.
World J Gastroenterol. Dec 1, 2004; 10(23): 3389-3393
Published online Dec 1, 2004. doi: 10.3748/wjg.v10.i23.3389
Table 1 Primer sequences and length of PCR products
GenePrimer sequenceSize of PCR product (bp)Reference
GSTM15’-GAACTCCCTGAAAAGCTAAAGC-3’219Lin et al
5’-GTTGGGCTCAAATATACGGTGG-3’1998[24]
GSTT15’-TTCCTTACTGGTCCTCACATCTC-3’459
5’-TCACCGGATCATGGCCAGCA-3’
Albumin5’-GCCCTCTGCTAACAAGTCCTAC-3’350
5’-GCCCTAAAAAGAAAATCCCCAATC-3’
GSTP15’-ACCCCAGGGCTCTATGGGAA-3’176Harries et al
5’-TGAGGGCACAAGAAGCCCCT-3’1997[16]
CYP1A15’-GGCTGAGCAATCTGACCCTA-3’206Cascorbi et al
5’-TTCCACCCGTTGCAGCAGGATAGCC-3’1996[8]
Table 2 Description of control and case populations
Control n (%)Case n (%)SCC n (%)ADC n (%)
Male87 (0.67)69 (0.87)44 (0.85)25 (0.93)
Female43 (0.33)10 (0.13)8 (0.15)2 (0.07)
Mean age (yr)56 [19; 87]62 [40; 85]60 [40; 78]66 [51; 85]
Tobacco duration12 (years of smoking)
Non-smokers66 (0 .66)6 (0.13)2 (0.07)4 (0.22)
1-1913 (0.13)2 (0.04)0 (-)2 (0.11)
+2021 (0.21)40 (0.83)28 (0.93)12 (0.67)
Alcohol consumption34 (g of ethanol per week)
0-22811 (0.64)13 (0.28)4 (0.14)9 (0.50)
228.5 - / + 4706 (0.36)35 (0.72)26 (0.86)9 (0.50)
Table 3 Repartition of CYP1A1 genotypes among controls and cases
nCYP1A1*1A/*1A
CYP1A1*1A/*2C
OR195%CI
n(%)n(%)
Controls107101(94)6(6)
Cases7061(87)9(13)All cases vs controls22.63[0.84-8.28]
SCC4740(85)7(15)SCC vs controls33.03[0.93-9.90]5
ADC2321(91)2(9)ADC vs controls42.06[0.33-13.04]
Table 4 Repartition of GSTM1 genotypes among controls and cases
nGSTM1*2/*2
OR195%CI
n(%)
Controls12059(49)
Cases6839(57)All cases vs controls21.43[0.76-2.69]
SCC4327(63)SCC vs controls31.83[0.88-3.83]5
ADC2512(48)ADC vs controls40.95[0.38-2.41]
Table 5 Repartition of GSTT1 genotypes among controls and cases
nGSTT1*2/*2
OR195%CI
n(%)
Controls11530(26)
Cases7014(20)All cases vs controls21.78[0.84-3.80]
SCC4413(29)SCC vs controls31.03[0.46-2.27]
ADC261(4)ADC vs controls413.31[1.66-106.92]a
Table 6 Repartition of GSTP1 genotypes among controls and cases
nGSTP1
OR1295%CI
Ile/Ile
Ile/Val
Val/Val
n(%)n(%)n(%)
Controls12459(48)56(45)9(7)
Cases7031(44)33(47)6(9)All cases vs controls31.02[0.55-1.89]
SCC4521(47)21(47)3(6)SCC vs controls40.95[0.47-1.91]
ADC2510(40)12(48)3(12)ADC vs controls51.17[0.46-2.97]