Mad2 and p27 expression profiles in colorectal cancer and its clinical significance

Table 1 Relationship between expression of Mad2 protein and histological differentiation and lymph node metastasis

Groups	n	Mad2		Positive (%)	P
		+	-
Normal tissue	40	18	22	45
Adenocarcinoma	40	30	10	75	0.01
WD	21	12	9	61.9
MD	11	10	1	99
PD	8	8	0	100	0.041
Lymph node metastasis
Absent	25	16	9	64
Present	15	14	1	88	0.038
Survival period (months)
< 18	12	9	3	75
≥ 18	28	9	19	32	0.013

WD: Well differentiated adenocarcinoma; MD: Moderately differentiated adenocarcinoma; PD: Poorly differentiated adenocarcinoma.

Table 2 Relationship among expression of p27 protein and histological differentiation and lymph node metastasis

Groups	n	p27		Positive (%)	P
		+	-
Normal tissue	40	32	8	80
Adenocarcinoma	40	16	24	40	0.001
WD	21	13	8	61.9
MD	11	2	9	18.2
PD	8	1	7	12.5	0.012
Lymph node metastasis
Absent	25	13	12	52
Present	15	3	12	20	0.046
Survival period after excision
< 18	12	4	8	33.3
≥ 18	28	12	16	42.9	0.573

WD: Well differentiated adenocarcinoma; MD: Moderately differentiated adenocarcinoma; PD: Poorly differentiated adenocarcinoma.