Expression of human augmenter of liver regeneration in pichia pastoris yeast and its bioactivity in vitro

Table 1 Effect of different dosages of hALR on HepG₂ and QGY proliferation (mean ± SD)

Cells	Control		Concentrations of hALR from yeast and E.coli
			0.1 ng	10 ng	1 μg	8 μg	16 μg
HepG2	7 174 ± 494	yeast	1 3779 ± 1 431a	13 679 ± 1 205a	15 279 ± 1 802a	22 670 ± 1 402bc	24 958 ± 1 326bc
		E.coli	1 0754 ± 2 756a	11 189 ± 1 447a	12 997 ± 1 683a	13 858 ± 440a	14 411 ± 1 452a
QGY	821 ± 11	yeast	2 549 ± 526bc	2 298 ± 203bc	3 188 ± 564bc	11 825 ± 841bc	17 021 ± 795bc
		E.coli	934 ± 50a	883 ± 106	1 222 ± 168a	1 362 ± 171a	6 209 ± 225b

^aP < 0.05,

^bP < 0.01 vs control;

^cP < 0.05 vs hALR from E.coli.