CDH1 germline mutation in hereditary gastric carcinoma

Table 1 CDH1 gene germline mutation patterns in HGC families

Ethnic background	Age at diagnosis	Mutation type	Mutation site
White	30-67	45insT	Exon 1
White	34-69	49-2A→G	Exon 2
-	-	53delC	Exon 2
White	27-50	59G→A	Exon 2
White	37-46	70G→T	Exon 2
Japanese	46-72	185G →T	Exon 31
White	33-69	187C →T	Exon 3
Maori	22-28	190C →T	Exon 3
White	41-47	283C →T	Exon 3
White	15-58	372-377del1	Exon 3
White	31-55	586G →T	Exon 5
Korean	30-63	731A →G	Exon 61
White	23-70	832 G →A	Exon 6
White	14-67	1008G→T	Exon 7
White	35-47	1018 A→G	Exon 81
African-American	29-58	1137 + 1G→A	Intron 8
Korean	42-49	1460T →C	Exon 101
White	32-40	1472insA	Exon 10
White	31	1487del7	Exon 10
-	-	1565 + 1 G→T	Intron 10
White	40-63	1588insC	Exon 11
-	-	1710delT	Exon 11
White	30-68	1711insG	Exon 11
White	23-43	1792C→T	Exon 12
White	30	2095C→T	Exon 13
-	-	2295 + 5 G→A	Exon 14
White	16-35	2381insC	Exon 15

¹Missence mutation; -No information obtained from the pub-lished paper.