Effect of resveratrol and in combination with 5-FU on murine liver cancer

Table 1 Suppressive effect of resveratrol on murine transplanted liver cancer (mean ± SD)

Group	Dose (mg/kg)	n	Tumor size (mm3)	Growth inhibitory rate (%)	t value
Control	0.0	9	134 ± 40	-
5-FU	20.0	9	63 ± 29	53.0	4.36b
RES	5.0	10	105 ± 14	21.6	2.16a
	10.0	10	85 ± 22	36.6	3.36b
	15.0	9	68 ± 17	49.3	4.33b

^aP < 0.05,

^bP < 0.01, vs control.

Table 2 Effect of RES on the number of H₂₂ cell cycles in transplanted liver cancer of mouse

Group	Dose (mg/kg)	n	Number of H22 cell cycles (%)
			G0/G1	S	G2/M
Control	0	9	0.29	0.60	0.11
RES	5.0	10	0.30	0.60	0.09
	10.0	10	0.30	0.68a	0.02a
	15.0	9	0.25	0.75a	0.00a

^aP < 0.05, vs control.

Table 3 Suppressive effect of RES in combination with 5-FU on murine with transplanted liver cancer (mean ± SD)

Group	Dose (mg/kg)	n	Tumor size (mm3)		t value	Growth inhibitory rate (%)
			Alone	With 5-FU		Alone	With 5-FU
Control	0	8	128 ± 33
RES	10.0	8	88 ± 21			31.5
5-FU	20.0	8	60 ± 12	29 ± 18	4.05b	53.4	77.4
	10.0	8	72 ± 17	35 ± 13	4.89b	43.8	72.4
	5.0	8	92 ± 19	64 ± 22	2.72a	28.4	50.0

^aP < 0.05,

^bP < 0.01, vs control.

Table 4 Effect of RES in combination with 5-FU on survival time and body mass of tumor bearing mouse (mean ± SD)

Group	Dose (mg/kg)	n	Last body mass(g )		t value	Survival time (d )		t value
			Alone	With 5-FU		Alone	With 5-FU
Control	0	8	23.6 ± 2.0			17.3 ± 3.3
RES	10.0	8	23.8 ± 1.2			21.5 ± 5.6
5-FU	20.0	8	16.5 ± 1.8	20.3 ± 1.3	4.79b	32.0 ± 9.7	44.6 ± 11.6	2.34a
	10.0	8	19.6 ± 1.8	23.2 ± 2.5	3.25b	23.6 ± 5.4	36.3 ± 9.4	3.22b
	5.0	8	21.3 ± 1.7	24.5 ± 1.5	3.80b	19.5 ± 4.4	30.6 ± 8.0	3.48b

^aP < 0.05,

^bP < 0.01, vs control.