Effects of estradiol on liver estrogen receptor-α and its mRNA expression in hepatic fibrosis in rats

Table 1 Serum ALT, AST, NO₂^-/NO₃^- and hepatic NOS activity (^-x±s)

Group	n	ALT	AST	NO2-/NO3-	NOS
		(nkat/L)	(nkat/L)	(μmol/L)	(KU/g)
Control	10	35.8 ± 7.9	64.5 ± 20.8	21.8 ± 13.7	0.65 ± 0.08
Ovx	10	31.6 ± 6.5	66.4 ± 18.3	19.3 ± 11.2	0.54 ± 0.33
Ovx+E	9	38.5 ± 11.2	68.4 ± 21.2	84.8 ± 24.9ac	2.57 ± 1.06ac
CCl4	9	540 ± 252a	631 ± 268a	55.3 ± 23.1a	1.65 ± 0.46a
CCl4+Ovx	10	658 ± 220a	697 ± 240a	53.7 ± 17.1a	1.73 ± 0.71a
CCl4+E	8	314 ± 163c	302 ± 153c	87.5 ± 23.6c	2.68 ± 1.17c
CCl4+Ovx+E	9	311 ± 146c	321 ± 121c	93.3 ± 24.2c	2.49 ± 1.20c

^aP < 0.05, vs control;

^cP < 0.05, vs CCl₄.

Table 2 Effects of ovariectomy and estradiol on histological scores of CCl₄– induced hepatic fibrosis

Group	n	Hepatic fibrosis scores
		-	+	++	+++	++++
Control	10	10	0	0	0	0
Ovx	10	10	0	0	0	0
Ovx+E	9	9	0	0	0	0
CCl4	9	0	2	2	3	1
CCl4+Ovxa	10	0	0	2	5	3
CCl4+Ea	8	0	4	2	1	0
CCl4+Ovx+Ea	9	0	5	2	2	0

^aP < 0.05, vs control.