Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis

Table 1 Rates of H pylori infection in various gastric mucosal lesions

Pathological diagnosis	n	H pylori rate (%)
CSG	30	36.7
GA	28	64.3a
IM	45	31.1
Dysplasia	12	33.3
Gastric cancer	23	69.5a

^aP < 0.05 vs CSG.

Table 2 Expression of COX-1 and COX-2 in gastric mucosa with various lesions

Pathological diagnosis	n	COX-1 expression (%)	COX-2 expression (%)
CSG	30	56.6	10.0
GA	28	53.8	35.7a
IM	45	53.3	37.8b
Dysplasia	12	41.7	41.7a
Gastric cancer	23	43.4	69.5bc

^aP < 0.05;

^bP < 0.01 vs CSG;

^cP < 0.05 vs GA.

Table 3 Relationship between H pylori infection and COX-1/COX-2 expression in the gastric mucosa with various lesions

Pathological diagnosis		n	COX-1				COX-2
			-	+	++	+++	-	+	++	+++
CSG	H pylori (+)	11	5	1	3	2	10	0	0	1
	H pylori (-)	19	8	3	4	4	17	1	1	0
GA	H pylori (+)	18	9	2	4	3	10	1	3	4
	H pylori (-)	10	4	2	2	2	8	1	1	0
IM	H pylori (+)	14	6	3	2	3	2	2	4	6b
	H pylori (-)	31	15	5	5	6	26	3	2	0
Dysplasia	H pylori (+)	4	2	0	1	1	0	0	2	2b
	H pylori (-)	8	5	0	1	2	7	0	1	0
Gastric cancer	H pylori (+)	16	9	2	2	3	5	1	3	7
	H pylori (-)	7	4	2	0	1	2	1	2	2

^bP < 0.01 vs H pylori (-).