Association of -238G/A polymorphism of tumor necrosis factor-alpha gene promoter region with outcomes of hepatitis B virus infection in Chinese Han population

doi:10.3748/wjg.v10.i12.1810

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 10, Issue 12

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (2285)

All Articles published online

The chart showing PDF series, HTML series, Tables (1-6) series.

Item

Count

PDF

192

HTML

1932

Tables (1-6)

154

Sum=2278

Jun 15, 2004 (publication date) through Apr 18, 2024

Times Cited of This Article

Times Cited (24)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Reports

World J Gastroenterol. Jun 15, 2004; 10(12): 1810-1814
Published online Jun 15, 2004. doi: 10.3748/wjg.v10.i12.1810

Table 1 Main characteristics of study groups

Variable	Chronic HB	Self-limited HBV	P
	n = 207(%)	infection n = 148 (%)
Age (mean ± SD)	40.06 ± 14.55	37.75 ± 13.35	0.40
Male/Female	162/45	70/78	< 0.01
Marital status			0.01
Married	162 (78.26)	131 (88.51)
Unmarried	45 (21.74)	17 (11.49)
Education level			0.06
Lower than high school	13 (6.28)	18 (12.16)
High school	126 (60.87)	94 (63.51)
Above high school	68 (32.85)	36 (24.32)

Table 2 Genotype and allele frequencies in subjects with chronic HB and self-limited HBV infection

Group	n	Genotype (%)¹			Allele (%)²
Group	n	A/A	A/G	G/G	A	G
Chronic HB	207	0 (0.0)	4 (1.93)	203 (98.07)	4 (0.97)	410 (99.03)
Self-limited HBV infection	148	0 (0.0)	10 (6.76)	138 (93.24)	10 (3.38)	286 (96.62)

¹χ² = 5.30, P = 0.02,

²χ² = 5.20, P = 0.02.

Table 3 Association of behavior factors with risk of chronic HB

Characteristics	Chronic HB (%)	Self-limited HBV infection (%)	OR (95%CI)	P
Cigarette smoking			1.40 (0.87, 2.28)	0.14
Yes	74 (35.75)	42 (28.38)
No	133 (64.25)	106 (71.62)
Alcohol consumption			1.26 (0.78, 2.05)	0.32
Yes	69 (33.33)	42 (28.38)
No	138 (66.67)	106 (71.62)

Table 4 Multivariate logistic regression analysis for determinants of chronic HB

Variable	β	χ²	P	OR	95%CI
Intercept	-0.5076	7.2203	0.0072	—	—
Sex (Male = 1, Female = 0)	1.4088	35.1138	< 0.0001	4.091	2.567–6.519
-238G/A (GG = 1, GA = 0)	1.4183	5.1467	0.0233	4.132	1.212–14.085

Table 5 Case-control analysis for interaction between ciga-rette smoking and GG genotype

Cigarette	GG	Case¹	Control²	*OR (95%CI)*	P
smoking	genotype
-	-	3	6	1	—
-	+	130	100	2.60 (0.56-13.49)	0.19
+	-	1	4	0.50 (0.01-10.45)	1.00
+	+	73	38	3.84 (0.79-20.73)	0.07

¹Chronic HB patients,

²self-limited HBV infection individuals.

Table 6 Case-control analysis for interaction between alcohol consumption and GG genotype

Alcohol	GG	Case¹	Control²	*OR (95%CI)*	P
consumption	genotype
-	-	3	7	1	—
-	+	135	99	3.18 (0.72-15.96)	0.11
+	-	1	3	0.78 (0.02-18.21)	1.00
+	+	68	39	4.07 (0.08-21.25)	0.05

¹Chronic HB patients,

²self-limited HBV infection individuals.

Citation: Lu LP, Li XW, Liu Y, Sun GC, Wang XP, Zhu XL, Hu QY, Li H. Association of -238G/A polymorphism of tumor necrosis factor-alpha gene promoter region with outcomes of hepatitis B virus infection in Chinese Han population. World J Gastroenterol 2004; 10(12): 1810-1814
URL: https://www.wjgnet.com/1007-9327/full/v10/i12/1810.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i12.1810