Retrospective Study
Copyright ©The Author(s) 2024.
World J Gastroenterol. Jul 28, 2024; 30(28): 3403-3417
Published online Jul 28, 2024. doi: 10.3748/wjg.v30.i28.3403
Table 3 Univariate and multivariate analysis of clinicopathologic variables in relation to overall survival and progression free survival in patients with rectal neuroendocrine neoplasms
Univariate analysis1
Multivariate analysis1
Univariate analysis2
Multivariate analysis2
HR (95%CI)
P value
HR (95%CI)
P value
HR (95%CI)
P value
HR (95%CI)
P value
Sex (male)1.148 (0.588-2.243)0.6861.168 (0.648-2.106)0.605
Age (> 60)2.194 (1.115-4.317)0.0232.875 (1.505-5.495)< 0.001
PLR (> 128.00)1.592 (0.818-3.100)0.1711.313 (0.668-2.577)0.402
NLR (> 1.45)1.629 (0.740-3.585)0.2262.322 (1.106-4.874)0.007
PNI (> 46.57)0.144 (0.071-0.295)0.0230.233 (0.109-0.499)< 0.0010.130 (0.043-0.392)< 0.0010.365 (0.135-0.583)0.010
Size (cm)
    ≤ 1-Ref.-Ref.-Ref.
    1-26.190 (2.591-14.790)< 0.0011.706 (0.538-5.413)0.3644.960 (1.956-12.580)0.001
    > 213.439 (5.563-32.468)< 0.0013.349 (1.314-8.533)0.01110.240 (5.200-25.200)< 0.001
Pathological type
    NET-Ref.-Ref.
    NEC31.177 (14.961-64.968)< 0.00115.121 (5.590-59.102)< 0.001
    MANEC27.899 (6.399-121.627)< 0.00126.252 (6.203-85.32)< 0.001
Pathological grade
    G1-Ref.-Ref.-Ref.-Ref.
    G26.380 (2.582-15.768)0.0014.211 (1.603-11.059)0.0048.680 (2.830-20.602)< 0.0012.937 (1.011-8.535)0.048
    G348.175 (21.495-107.969)< 0.00130.681 (10.821-86.988)< 0.00125.362 (6.362-62.325)< 0.0017.126 (2.685-18.913)< 0.001
T stage
    T1-Ref.-Ref.-Ref.
    T23.234 (1.169-8.945)0.02413.370 (3.794-47.086)< 0.0012.136 (1.236-5.362)0.025
    T317.473 (7.846-38.915)< 0.00112.630 (2.635-18.354)< 0.0016.653 (2.368-15.362)0.001
    T423.081 (8.328-63.964)< 0.00126.368 (5.364-53.258)< 0.0018.365 (3.325-13.325)< 0.001
Lymph node metastasis (yes)11.387 (5.786-22.409)< 0.00112.440 (4.172-37.112)< 0.001
TNM stage
    I-Ref.-Ref.
    II3.280 (1.188-9.056)0.0226.839 (1.692-27.650)0.006
    III14.524 (7.080-29.797)< 0.00117.792 (5.982-52.932)< 0.001
Lymph vascular invasion (yes)5.753 (2.013-16.447)0.0015.899 (1.213-28.703)< 0.001
CgA (positive)1.992 (1.012-3.919)0.0461.188 (0.608-2.322)0.512
Syn (positive)1.161 (0.541-2.492)0.7020.960 (0.483-1.908)0.919
Adjuvant therapy (yes)10.775 (5.161-22.499)< 0.00113.110 (3.737-45.962)< 0.001