Raf kinase inhibitor protein combined with phosphorylated extracellular signal-regulated kinase offers valuable prognosis in gastrointestinal stromal tumor

Table 4 Multivariate analysis of prognostic factors for overall survival of gastrointestinal stromal tumors with two different sets of risk factors, n = 63

Characteristic	n	Multivariate1			Multivariate2
		HR	95%CI	P valuea	HR	95%CI	P valuea
Tumor location
Stomach	36	2.59	0.69-9.69	0.156	4.13	1.07-15.98	0.04
Duodenum	12
Jejunoileum	15
Tumor size in cm
< 2	11	1.92	0.93-3.96	0.079	1.17	0.52-2.62	0.71
2-5	19
6-10	18
> 10	14
Mitotic figures as /50 HPFs
0	11	1.22	0.71-2.10	0.472	1.28	0.75-2.18	0.361
1-4	36
5-10	5
> 10	11
RKIP expression
Positive	35				0.13	0.03-0.66	0.014
Negative	28
P-ERK expression
Positive	36				0.91	0.19-4.32	0.909
Negative	27

¹Analysed factors were tumor location, tumor size, mitotic figures; above are all the risk factors included in NIH 2008 Risk Grade System.

²Analysed factors were tumor location, tumor size, mitotic figures, raf kinase inhibitory protein (RKIP) expressions and phosphorylated-extracellular-signal regulated kinase (P-ERK) expressions.

^aP < 0.05 were considered statistically significant.

HPFs: High-power fields; HR: Hazard ratio; MAPK: Mitogen-activated protein kinase; P-MEK: Phosphorylated MAPK\ERK kinase.