Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice

Figure 8 Interleukin-34 expression was elevated in inflamed mucosa and associated with colonic epithelium proliferation in active ulcerative colitis. A: Representative microscopic pictures of interleukin-34 (IL-34) immunohistochemical staining in colonic biopsies of healthy controls or individuals with active ulcerative colitis (UC); B: Percentage of IL-34-positive cells per high-power field were quantified in colonic biopsies of healthy controls (n = 20) and active UC patients (n = 40); C: Representative photomicrographs of immunostaining of Ki67 in colonic biopsies of active UC patients in IL-34 Lower expression and higher expression groups; D: Correlation analysis of colonic IL-34 expression and Ki 67-positive cells in active UC patients. IL-34: Interleukin-34; UC: Ulcerative colitis. Scale bar indicates 100 μm or 200 μm. ^dP < 0.001.