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©The Author(s) 2022.
World J Gastroenterol. Oct 21, 2022; 28(39): 5658-5665
Published online Oct 21, 2022. doi: 10.3748/wjg.v28.i39.5658
Published online Oct 21, 2022. doi: 10.3748/wjg.v28.i39.5658
Factor | Disease | Risks of small intestinal adenocarcinoma | Ref. |
Animal fat | Correlation coefficient of 0.61 | [21] | |
Animal protein | Correlation coefficient of 0.75 | [21] | |
2–3-fold higher risk | [36] | ||
Bile salts | Bile salts may transform into carcinogenic deoxycholic acid | [22] | |
Hereditary polyposis | FAP | APC mutation; 5% is small bowel adenocarcinoma and half is duodenal adenocarcinoma | [27] |
The incidence is 330 times higher than that in the general population | [28] | ||
HNPCC | MMR gene mutation; lifetime risk is at approximately 1% in a French registry | [29] | |
PJS | STK11 mutation; incidence is 520 times higher than that in the general population | [30] | |
Disease | Crohn’s disease | The incidence is 17.4 times higher than that in the general population | [37] |
The incidence is almost 3 times higher than that in the average American | [38] | ||
Celiac disease | It is implicated in 8%-13% of small bowel adenocarcinoma cases | [39,40] |
- Citation: Fujimori S, Hamakubo R, Hoshimoto A, Nishimoto T, Omori J, Akimoto N, Tanaka S, Tatsuguchi A, Iwakiri K. Risk factors for small intestinal adenocarcinomas that are common in the proximal small intestine. World J Gastroenterol 2022; 28(39): 5658-5665
- URL: https://www.wjgnet.com/1007-9327/full/v28/i39/5658.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i39.5658