Copyright ©The Author(s) 2022.
World J Gastroenterol. Sep 14, 2022; 28(34): 4959-4972
Published online Sep 14, 2022. doi: 10.3748/wjg.v28.i34.4959
Table 2 Efficacy of cytapheresis in patients with ulcerative colitis showing previous biologics failure
Study type
Biologics exposure
Number of patients (total number of patients in the study)
Regimen of CAP
Rate of remission
Rate of steroid-free remission
Cabriada et al[35], 2012Retrospective study (results of nationwide Spanish registry)IFX33 (total: 142 SD)GMA (95% of the Pts), 1-10 sessions (median 5 sessions)37% (all Pts), no differences in clinical remission were found among those Pts with previous thiopurine or IFX failure
Dignass et al[36], 2016Single-arm, open-label, multicentre trialTNF-α37 (total: 86 SD)GMA (5-10 sessions, 1 session/wk)27.8% (Pts who failed on TNF-α), 40.3% (Pts who failed on immunosuppressants
Yamamoto et al[37], 2018Retrospective study(1) IFX; and (2) ADA(1) 31; and (2) 36 (total: 593)GMA (5 sessions, 1 to 5 sessions/wk), 5 or 6 GMA were added in Pts who did not achieve clinical remission31% (Pts exposed to biologics), 48% (Pts unexposed to biologics), P = 0.01