Copyright ©The Author(s) 2020.
World J Gastroenterol. Sep 7, 2020; 26(33): 4900-4918
Published online Sep 7, 2020. doi: 10.3748/wjg.v26.i33.4900
Figure 4
Figure 4 Role of cancer-associated fibroblasts in cholangiocarcinoma. In the figure is shown the paracrine loop between tumor cells and cancer-associated fibroblasts, the main cellular component of cholangiocarcinoma tumor microenvironment (TME). Several survival and recruitment signals are exchanged within TME, leading to tumor growth and progression. CCA: Cholangiocarcinoma; TGFβ: Transforming growth factor beta; PDGF-β: Platelet-derived growth factor receptor beta; EGFR: Endothelial growth factor receptor.