Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells

doi:10.3748/wjg.v26.i33.4900

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Sep 7, 2020 (publication date) through Apr 16, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2020; 26(33): 4900-4918
Published online Sep 7, 2020. doi: 10.3748/wjg.v26.i33.4900

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Figure 4 Role of cancer-associated fibroblasts in cholangiocarcinoma. In the figure is shown the paracrine loop between tumor cells and cancer-associated fibroblasts, the main cellular component of cholangiocarcinoma tumor microenvironment (TME). Several survival and recruitment signals are exchanged within TME, leading to tumor growth and progression. CCA: Cholangiocarcinoma; TGFβ: Transforming growth factor beta; PDGF-β: Platelet-derived growth factor receptor beta; EGFR: Endothelial growth factor receptor.

Citation: Polidoro MA, Mikulak J, Cazzetta V, Lleo A, Mavilio D, Torzilli G, Donadon M. Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells. World J Gastroenterol 2020; 26(33): 4900-4918
URL: https://www.wjgnet.com/1007-9327/full/v26/i33/4900.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i33.4900