Copyright ©The Author(s) 2020.
World J Gastroenterol. Jun 14, 2020; 26(22): 2948-2966
Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.2948
Table 1 Comparison of type 1, type 2 and surgically induced diabetes mellitus
Type 1 DMType 2 DMType 3 DM
PathogenesisChronic autoimmune disorder; the immune system attacks endogenous pancreatic β-cellsProgressive metabolic disorder characterized by insulin resistanceChronic disorder induced by partial or total pancreatectomy
Prevalence5% to 10% of diagnosed diabetics90% to 95% percent of diagnosed diabetics1% of diagnosed diabetics
OnsetAbruptGradualShortly after surgery
Age of onsetVaries (commonly in childhood or puberty)Commonly over 35 yrCommonly over 50 yr
Genetic predispositionModerateVery strongModerate
Body habitusThin or normalOften obeseNormal, overweight or obese
β-cell depletionSevere (over 80%)Mild (24% to 65%)Mild to total (up to 100%)
Plasma insulinLow to absentNormal or increasedLow to absent