Copyright ©The Author(s) 2020.
World J Gastroenterol. May 21, 2020; 26(19): 2305-2322
Published online May 21, 2020. doi: 10.3748/wjg.v26.i19.2305
Table 2 Definitions of American Joint Committee on Cancer and European Neuroendocrine Tumor Society staging for pancreatic neuroendocrine tumors
AJCC 7th staging classificationAJCC 8th and ENETS staging classification
T1Limited to the pancreas, ≤ 2 cm in greatest dimensionT1Tumor limited to the pancreas, ≤ 2 cm
T2Limited to the pancreas, > 2 cm in greatest dimensionT2Tumor limited to the pancreas, 2-4 cm
T3Beyond the pancreas but without involvement of the superior mesenteric arteryT3Tumor limited to the pancreas, > 4 cm, or invading the duodenum or common bile duct
T4Involvement of the celiac axis or superior mesenteric artery (unresectable tumor)T4Tumor invades adjacent structures
N0No regional lymph node metastasisN0No regional lymph node metastasis
N1Regional lymph node metastasisN1Regional lymph node metastasis
M0No distant metastasisM0No distant metastasis
M1Distant metastasisM1Distant metastasis
M1aMetastasis confined to liver
M1bMetastasis in at least one extrahepatic site
M1cBoth hepatic and extrahepatic metastases