Basic Study
Copyright ©The Author(s) 2019.
World J Gastroenterol. Feb 7, 2019; 25(5): 584-599
Published online Feb 7, 2019. doi: 10.3748/wjg.v25.i5.584
Figure 6
Figure 6 Increased intestinal proliferation in Cldn7 ICKO mice. A-D: Immunohistochemistry staining showed that Cldn7 was strongly expressed in the intestinal epithelial junctions of control mice but significantly weakened in ICKO mice; E-H: In control mice, Ki67 was mainly distributed in parts of the crypt, while Ki67-positive cells occupied the entire intestinal crypt and could be observed throughout the intestinal villi in ICKO mice; I-J: The size of the intestinal crypt in ICKO mice was increased compared with that in control mice (P < 0.001). Cldn7: Claudin-7; ICKO: Inducible conditional knockout.