Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis

doi:10.3748/wjg.v25.i33.4933

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Sep 7, 2019; 25(33): 4933-4944
Published online Sep 7, 2019. doi: 10.3748/wjg.v25.i33.4933

Table 3 Hospital admissions for hepatic decompensation for proton pump inhibitor users and non-users with decompensated liver cirrhosis

	Number of patients	Hospital admissions for liver decompensation
	Number of patients	Adjusted RR (95%CI)	P value
Entire cohort	PPI user = 335 Non-user = 116	1.61 (1.30-2.11)	< 0.001
Dose exposure
Non-user	116	Ref
cDDD 28-90	49	0.65 (0.39-1.08)	0.10
cDDD 91-180	61	1.08 (0.74-1.59)	0.69
cDDD > 180	225	1.91 (1.49-2.45)	< 0.001

cDDD: Cumulative defined daily dose; RR: Relative risk; CI: Confidence interval; PPI: Proton pump inhibitor.

Citation: De Roza MA, Kai L, Kam JW, Chan YH, Kwek A, Ang TL, Hsiang JC. Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis. World J Gastroenterol 2019; 25(33): 4933-4944
URL: https://www.wjgnet.com/1007-9327/full/v25/i33/4933.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i33.4933