Copyright ©The Author(s) 2019.
World J Gastroenterol. Aug 7, 2019; 25(29): 3897-3919
Published online Aug 7, 2019. doi: 10.3748/wjg.v25.i29.3897
Table 6 Recommended treatment regimens for hepatitis C virus GT4 infection
Recommendation categoryTreatment option(s)Treatment regimen
PreferredLDV + SOF ± RBVLDV + SOF for 12 wk [Addition of RBV may be considered based on the physician’s discretion in treating difficult-to-treat patients (treatment-experienced patients, patients with cirrhosis)].
In case of previous SOF treatment failure: LDV + SOF + RBV for 12 wk
AlternativeSOF + DCV ± RBVSOF + DCV for 12 wk (Addition of RBV may be considered if cirrhosis has not been conclusively ruled out.)
Cirrhosis of any class: SOF + DCV + RBV for 12 wk
If RBV is ineligible, SOF + DCV for 24 wk
Not recommendedDue to the advent of newer DAAs, pegylated interferon, boceprevir, and telaprevir-based regimens are not recommended.