Copyright ©The Author(s) 2019.
World J Gastroenterol. Jun 28, 2019; 25(24): 3009-3020
Published online Jun 28, 2019. doi: 10.3748/wjg.v25.i24.3009
Table 1 Nonalcoholic fatty liver disease subtype classification
NAFLD subtypeCharacteristicsMouse model-based classificationTreatments tested
M-SubtypeIncreased fatty acid uptake.Mat1a KO[37]SAMe
Low liver glutathione and SAMe content.0.1MCD[59]Aramchol
Reduced synthesis of PC-PUFA.
Abnormal VLDL-TG assembly and export.
Non-M-SubtypeIncreased DNL.Ldlr KO/HFD[68]Obeticholic acid
Normal hepatic SAMe levels.
Normal VLDL-TG secretion.
High serum levels of cholesterol and TG.