MicroRNA-596 acts as a tumor suppressor in gastric cancer and is upregulated by promotor demethylation

Figure 1 MicroRNA-596 is downregulated and peroxiredoxin 1 upregulated in gastric cancer tissues and cell lines. A and B: Expression of miR-596 in 55 pairs of gastric cancer (GC) and non-tumor tissues (A) and human GC cells (B). C and D: Expression of peroxiredoxin 1 (PRDX1) mRNA in 55 GC samples and corresponding non-tumor tissues (C) and human GC cells (D). E: Pearson's correlation analysis of the relative expression levels of miR-596 and the relative PRDX1 mRNA expression levels in the same set of patients. β-actin was used as an internal control. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs non-tumor tissues or GES-1. PRDX1: Peroxiredoxin 1; MiR-596: MicroRNA-596.