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Copyright ©The Author(s) 2019.
World J Gastroenterol. Jan 7, 2019; 25(1): 59-68
Published online Jan 7, 2019. doi: 10.3748/wjg.v25.i1.59
Table 2 Summary of recent randomized control trials evaluating intensive vs less intensive surveillance strategies
TrialSettingEnrollment periodPatient populationIntensive groupControl groupResults
FACS (JAMA 2014)[23]United Kingdom2003-20091201 stage I-IIIEither: CEA every 3 mo for 2 yr, then every 6 mo for 3 yr, with a single chest, abdomen, and pelvis CT scan at 12-18 mo if requested; CT of the chest, abdomen, and pelvis every 6 mo for 2 yr, then annually for 3 yr; Both blood CEA measurement and CT imaging as aboveNo scheduled follow-up except a single CT scan of the chest, abdomen, and pelvis at 12-18 mo if requestedNo difference in overall mortality for combined CEA and CT compared to minimal follow-up
GILDA (Ann Oncol 2016)[22]Italy1998-20061228 Dukes B2-C (high risk stage II and III)Office visit, blood tests (CEA, CBC, liver tests, CA19-9) every 4 mo for 2 yr, then every 6 months for 2 yr then at 5 yr; Colonoscopy and chest X-ray every year for 5 yr; Liver ultrasound at 4, 8, 12, 16, 24, 36, 48, and 60 moOffice visit, CEA, every 4 mo for 2 yr, then every 6 mo for 2 yr then at 5 yr; Colonoscopy at 1 yr and at 4 yr; Liver ultrasound at 8 and 20 moNo difference in overall survival or health-related quality of life scores
COLFOL (JAMA 2018)[11]24 centers in Sweden, Denmark, and Uruguay2006-20102509 stage II and IIICEA and CT thorax/abdomen at 6, 12, 18, 24, and 36 moCEA and CT thorax/abdomen at 12 mo and 36 moNo difference in overall mortality, cancer-specific mortality, and cancer recurrence
PRODIGE-13[24]96 centers in France and Belgium2009-20151997 stage II and IIIClinical assessments every 3 mo until year 3 and every 6 mo until year 5, then at least yearly thereafter; Alternating assessments every 3 mo of CT thorax/abdomen/pelvis or abdominal ultrasound until year 3 and then every 6 mo until year 5; Colonoscopy at 3 yr after surgery then every 3 to 6 yr thereafterClinical assessments every 3 mo until year 3 and every 6 mo until year 5, then at least yearly thereafter; Abdominal ultrasound every 3 mo until year 3 and then every 6 mo until year 5; chest X-ray every; 6 mo until year 3 and then annually until year 5; Colonoscopy at 3 yr after surgery then every 3 to 6 yr thereafterPending for 2021