Recovery of natural killer cells is mainly in post-treatment period in chronic hepatitis C patients treated with sofosbuvir plus ledipasvir

Figure 3 Effect of sofosbuvir and ledipasvir therapy on the frequencies of natural killer cell subsets from chronic hepatitis C patients. A: Frequencies of CD56⁺ natural killer (NK) cells in peripheral blood mononuclear cells (PBMCs); B: Frequencies of CD56^bright NK cells in PBMCs; C: Frequencies of CD56^dim NK cells in PBMCs. ^aP < 0.05 and ^bP ≤ 0.01 and ^cP ≤ 0.001, different time points of CHC patients vs healthy controls; ^dP < 0.05 and ^eP ≤ 0.01 and ^fP ≤ 0.001, different time points of CHC patients (2 wk, 4 wk, 8 wk, 12 wk, Pt-12 wk, Pt-24 wk vs 0 wk). NK: Natural killer; CHC: Chronic hepatitis C; Ctrl: Healthy controls; Pt: Post of treatment; PBMCs: Peripheral blood mononuclear cells.