Systematic Reviews
Copyright ©The Author(s) 2018.
World J Gastroenterol. Jul 7, 2018; 24(25): 2741-2763
Published online Jul 7, 2018. doi: 10.3748/wjg.v24.i25.2741
Table 1 Summary of included pediatric-onset inflammatory bowel disease incidence studies stratified by continent and geographical areas
Country/Region/ProvinceAge (yr)Study periodIBD incidenceCD incidenceUC incidenceIBDU incidenceSettingYear of publicationFirst author /referenceRepresentativeness of the case
Western and North Europe
Austria/Styria< 181997-20076.7 a4.8aR2013Petritsch W et al[122]B
Denmark/Eastern< 151998-20004.3.2.3.1.8.0.2R2002Urne et al[108]B
Denmark< 171995-2013P2016Larsen et al[109]A
20139.7a6.7a
Denmark/Eastern< 151998-20096.4a3.2a,b3.1a,b0.2aR2011Jakobsen et al[110]B
Denmark< 151995-20123.1a2.7aP2014Norgard et al[111]A
Denmark/Eastern< 151998-20004.3a2.3a1.8a0.2aP2008Jakobsen et al[33]B
2002-20046.13.12.70.3
Denmark< 151980-20132.4a3.3aP2017Lophaven et al[103]A
Denmark/Copenhagen County< 191962-19878.6-13.3aP1991Langholz et al[106]B
Denmark/Copenhagen County< 141962-19872.2a0.2a2.0aP1997Langholz et al[105]B
Denmark/Copenhagen County< 141962-19870.2R1992Munkholm et al[62]B
Denmark/Copenhagen County< 151962-19870.2-3.1a2 - 1.6aP2009Jakobsen et al[34]B
Denmark< 151981-19920.8a2.5aP1997Fonager et al[107]A
Denmark/Northern< 141978-20021.52.7P2006Jacobsen et al[104]B
Denmark/Copenhagen County< 172003-20054.45.5P2006Vind et al[102]B
Finland< 181987-20035a2a4aP2011Lehtinen et al[65]A
20031559.1
Finland< 171987-2003P2006Turunen et al[64]A
19873.9a1.7a2.2a
200373.64.81
Finland< 171986-19921.0aR1998Pebody et al[88]A
Finland< 181987-20036.52.14.1P2016Lehtinen et al[89]A
Finland< 191987-20147-23a6-8a10-15aR2017Virta et al[66]A
< 162011-2014138
France< 171988-20113.1-6.3aP2016Bequet et al[126]A
France/Northern< 171998-19993.1a2.3a0.8a0.12aP2005Auvin et al[43]B
France/Northern< 171988-20114.4a3.2a1.1a0.1aP2017Ghione et al[131]B
France/Brittany< 171994-19972.51.60.57P2000Tourtelier et al[131]B
France/Northern< 191988-20073.4-5.9aP2011Chouraki et al[32]B
France/Northern< 171988-20022.6P2008Vernier-Massouille et al[127]B
France/Northern< 191988-20086.5-12.9aP2013Gower-Rousseau et al[125]B
France/Corsica< 192002-200312.36.2P2007Abakar-Mahamat et al[128]B
France/Nord-Pas-de-Calais< 171988-19893.12.10.5P1991Gottrand et al[130]B
The Farose Islands< 191960-20149.02a2.52a52a1.52aP,R2016Hammer et al[19]A
Iceland< 161950-2010P,R2013Agnarsson et al[29]A
1951-19601.20.21.1
1961-19700.90.10.7
1971-19800.90.10.7
1981-19902.5a1.2a1.2a0.1a
1991-2000/2001-20105.6/5.02.5/2.32.5/2.30.3/0.3
Iceland< 191990-19944.55P2000Bjornsson et al[112]A
Ireland< 162000-20102.5-5.6a2.3a1.1aR2012Hope et al[120]A
Ireland< 102000-20140.8-3.3aP,R2017Coughlan et al[121]A
The Netherlands< 181999-20015.22.11.63.6P2004van der Zaag-Loonen et al[124]A
Germany/Southern< 152004-20064.0a2.4a1.1aP2008Ott et al[123]B
Norway/Southeastern< 161990-19944.222.1P2002Bentsen et al[85]B
Norway/Southeastern< 141990-19931.3P1996Moum et al[95]B
Norway/Southeastern< 161990-19934.72.72P2004Stordal et al[93]B
Norway/Southeastern< 182005-200710.9b6.8b3.6b0.6P2009Perminow et al[92]B
Norway/Southeastern< 161993-20045.6-5.7a2.0-3.6a3.7-2.1aP,R2006Perminow et al[60]B
Norway/Western< 161984-19856.82.54.30P1989Olafsdottir et al[97]B
Norway/Western< 141984-19852.5P1988Haug et al[163]B
Norway/Souteastern< 14199031.20.6P1995Moum et al[94]B
Norway/Southeastern< 141990-19930.94P1996Moum et al[96]B
Sweden/Northern Stockholm< 171990-19986.9a3.8a2.1a1.1aR1999Askling et al[99]B
Sweden/Northern Stockholm< 151990-20017.4a4.9a2.2a0.2aP2003Hildebrand et al[59]B
Sweden/Soutwestern< 161983-19875.32.72.60.7P1994Hildebrand et al[164]B
Sweden/Stockholm< 152002-200712.8a,b9.2a,b2.8a,bP2013Malmborg et al[38]B
Sweden< 151984-19954.6-7.0a1.2-1.3a1.4-3.2a1.1aP2000Lindberg et al[68]A
Sweden< 141963-19671.4 - 0.7aR1991Lindberg et al[98]A
1983-19870.7
Sweden/the Uppsala region< 172005-200918.98.9P2013Sjoberg et al[100]B
Sweden/the Uppsala region< 172005-200910P2014Sjoberg et al[101]B
Sweden/the Uppsala region< 191965-1983R1991Ekbom et al[56]B
1965-19705.9-5.0a5.2-4.8a
1975-19834.8-3.23.9-2.7
Sweden/Orebro< 191963-19876R1992Tysk et al[165]B
Sweden/Stockholm County< 141955-19834.1R1997Lapidus et al[35]B
Sweden< 151984-19854.81.71.7P1991Hildebrand et al[166]A
UK/ Scotland< 162003-20087.8a4.8a2.1a1.0aP,R2012Henderson et al[2]A
1990-19954.52.91.6
UK/Wesex Southern England< 162002-2012/2013-20172014, 2018Ashton et al Ashton et al[116,117]B
2002-20066.4a,b3.8a,b2.0a,bP
2008-20129.45.92.6
UK/Scotland< 161981-19953.42.3a1.2aR2004Armitage et al[114]A
UK/Wales< 161996-20035.43.61.5P2006Ahmed et al[30]B
UK/Wales< 161995-19972.61.40.80.5P2000Hassan et al[118]B
UK/Wales< 161981-19952.5a1.3aR2001Armitage et al[53]B
UK/Northeastern Scotland< 161980-1999
1980-19892.20.7R2002Watson et al[115]B
1990-19994.41.5
UK/Scotland< 161968-19830.7-2.3a1.9-1.6aR1989Barton et al[61]A
UK/Cardiff< 161996-20052.7R2007Gunesh et al[119]B
UK/Leicestershire< 101972-19890.3a,dR1992Probert et al[27]B
UK/Wales South Glamorgan< 161983-19932.2a0.7aR1996Cosgrove et al[57]B
1983-19881.30.7
1989-19933.10.7
UK/British Isles and Ireland< 161998-19995.3a,d3.1a,d1.4a,d0.6dP2001Sawczenko et al[16]A
UK/Scotland< 191990-19922.9aR1999Armitage et al[113]A
UK/East London< 201997-20012.3-7.3a,d2.4-8.1a,dR2004Tsironi et al[17]
Northern America
Canada/Manitoba< 171978-20076.9a1.2-4.7a0.5-1.6aP2014El-Matary et[79]B
Canada/Metropolitan Toronto< 171991-19963.72.7R2004Griffiths[82]B
Canada/ 5 Provinces< 161999-20109.7a6.5a2.4aR2017Benchimol et al[31]A
Alberta9.75.92.7
Manitoba7.24.22.8
Nova Scotia15.29.34.2
Ontario9.35.53.2
Quebec10.38.81
Canada/Suothwestern Ontario< 171997-200613.3a4.9a8.1a0.3aR2009Grieci et al[81]B
1997-200114.33.510.60.2
2002-200612.4660.4
Canada/Ontario< 181994-2005P2009Benchimol et al[54]B
19949.5a6.2a4.4a
200511.474.8
Canada/Ontario< 191999-2008P2014Benchimol et al[84]B
0-92.9a1.3a1.3a0.3
10-1921.512.87.61.1
Canada/British Columbia< 161985-20055.2d3.7d1.0d0.5dR2007Pinsk et al[18]B
15.26.46.72.1
Canada/Ontario< 181994-20099.4-13.2a5.2-7.9a3.9-4.1aR2014Benchimol et al[84]B
Canada/Eastern< 201996-200914-11a2c4-6a2c0-1.5a2cP2014Leddin et al[83]B
Canada/Quebec< 192001-2008R2014Bitton et al[78]B
0-92.0a1.0a
10-19204
Canada/ 5 Provinces< 191998-2000P2006Bernstein et al[39]A
Alberta9.4a4.1a
British Columbia5.43.2
Manitoba6.94.5
Nova Scotia125.7
Saskatchewan7.94.2
Canada/Qubec< 191993-200213.9P2009Lowe et al[80]B
U.S.A./Northern Carolina< 171996-20062.2-4.3a,d1.8-4.9a,d0.5dR2010Abramson et al[20]B
U.S.A/Wisconsin< 182000-20017.05d4.6d2.1dP2003Kugathasan et al[21]B
U.S.A/Wisconsin< 182000-20079.5a,d6.6a,d2.4a,d0.5a,dP,R2013Adamiak et al[22]B
U.S.A/Georgia< 191986-19958.8a,d5.3a,dR1998Ogunbi et al[23]B
U.S.A/Texas< 171991-2002R2010Malaty et al[52]B
1991-19961.1a0.7a0.3a0.1a
1997-20022.41.30.50.7
U.S.A/Olmstedt Minesota< 191940-20003.4a2.4aR2007Loftus et al[58]B
1990-20004.83.2
U.S.A/Olmstedt Minesota< 141943-19820.75aR1988Gollop et al[167]B
U.S.A/Olmstedt Minesota< 191940-19932.5aR1998Loftus et al[36]B
U.S.A/Northern California< 181996-200232.9R2008Herrinton et al[76]B
U.S.A/Olmstedt Minesota< 191940-19931.8R2000Loftus et al[168]B
U.S.A/Rhode Island< 192008-2010P2016Shapiro et al[77]B
0-94.5a1.1a0.0a
10-1920.68.60.7
Latin America
Argentina/Provinces< 182012-2013
Argentina0.4P2017Vincentin et al[87]A
Buenos Aires0.3
CABA2.4
Chaco0.3
Cordoba0.3
Corrientes0.6
Entre Rios0.8
Mendoza0.2
Misiones0.9
San Juan1
Tucana0.2
Africa
Libya/Eastern/Benghazi< 151997-2006R2009Ahmaida et al[146]B
19970.0a
20000.2
20060.9
Asia /Middle East
Saudi Arabia< 142003-20120.50.30.2R2014El Mouzan et al[149]A
Saudi Arabia/Riyadh< 181993-20020.5R2006El Mouzan et al[150]B
Kuwait< 151998-20082.21.50.60.03R2011Al-Quabandi[151]A
Israel/Tel Aviv< 191970-19801P1989Grossman et al[148]B
Israel/Southeastern< 191968-19923.6R1994Odes et al[147]B
the Kingdom of Bahrain< 191990-20153.7aP,R2017Zayyani et al[152]A
1990-19951.8
2010-20157.6
Taiwan< 181979-2000R2004Tsai et al[154]A
1979-19950.9a0.9a
1996-20002.61
Singapore< 181996-2009R2013Chu et al[155]A
20002.2a
200811.4
Taiwan< 192000-2010R2015Chia Jung Kuo et al[169]A
0-90.1a0.1a
10-190.20.2
Korea/South< 192011-20142017Jung et al[157]B
10-141.622.02P
15-198.224.82
China/Shangahai< 182000-20105.5a2.9a2.5aR2013Wang et al[153]B
Korea/Seoul< 191986-1997R2000Yang et al[156]B
0-91986-1995/1995-19970-0.2
Australasia10-191986 -1995/1995-19970.2-0.9
Australia/Randwick< 161987-201133.1-4.3dR2014Naidoo et al[24]B
Australia/Victoria< 161971-20010.1-2.0aR2003Phavichitr et al[158]B
Australia/Victoria< 161983-19982.0aR2009Ponsonby et al[37]B
Australia/Victoria< 161950-20090.4-1.6aR2013Schildkraut et al[159]B
New Zealand< 1620155.23.510.7P2017Lopez et al[160]A
New Zealand/Canterburry< 161996-20157.2aP2018Lopez et al[161]B
New Zealand< 152002-20032.9d1.9d0.5dP2008Yap et al[26]A
Sousthern Europe
Italy/Florence< 151978-19921.9-3.4a3.8-9.6aR1996Trallori et al[136]B
Italy/Lazio< 192008-2009R2014Domenicantonio et al[135]B
0-92.52
10-198.727.52
Italy< 181996-20030.9-1.4aP2008Castro et al[63]A
Italy/Lombardia< 141990-19931.21.21996Ranzi et al[134]B
Spain< 181996-20091.0-2.8a,b0.5-1.7a,b0.4-0.9a,bR2013Martin de Carpi et al[42]A
Spain/the Vigo area< 15201018.310.38.71.2P2015Fernandéz et al[50]B
Spain/Navarra< 142001-20032.61.70.90.6P2008Letamendia et al[137]B
Spain< 181985-19950.2a1R2014Martin de Carpi et al[51]A
Spain/Asturias< 141993-20000.30.20.1P,R2004Fernandez Gonzalez[170]B
Spain/Northern< 142000-20025.81.6P2004Rodrigo et al[44]B
Spain/Aragon< 141992-19950.4a0.3aP1999Lopez Miguel et al[171]B
Malta< 151993-20051.3a7.9aR2008Cachia et al[138]A
Central and Eastern Europe
Croatia/Primorsko-Goranska< 182000-20048.70.9P2006Sincic et al[47]B
Czech Republic/Moravia< 161998-20012.2a2.7a1.8a0.3aR2004Kolek et al[140]B
Czech Republic< 151990-20010.3-.1.3aP,R2006Pozler et al[139]A
Czech Republic/West Bohemia< 192000-201510.0a6.2a2.8a1.0aP2017Schwarz et al[45]B
< 157.34.620.7P
Hungary< 162007-20097.54.72.30.5P2013Muller et al[141]A
Hungary/Veszprem< 191977-20110.0-7.2a0.7-5.2aP,R2014Lovasz et al[46]B
Slovenia/Northestern< 182002-20107.64.62.8R2014Urlep et al[49]B
2002-20045.73.91.8
2008-20108.953.4
Slovenia< 182002-20107.6a,b4.5a,b2.9a,b0.2a,bR2015Urlep et al[48]A
2002-20045.83.62.2
2005-20078.65.13.2
2008-20108.44.93.2
Slovenia/Western< 171994-20054.0a2.4a1.1a0.5aR2009Orel et al[143]B
1994-1999320.80.3
2000-20055.12.91.60.69
Yugoslavia/Zagreb Croatia< 141980-19891.76P,R1991Vucelic et al[145]B
Yugoslavia/Zagreb Croatia< 141980-19893.1P,R1991Vucelic et al[144]B
Poland< 182002-20042.70.61.30.8P2009Karolewska-Bochenek et al[67]A
Hungary/Western< 181977-20087.5a5.5aP2011Lakatos et al[142]B