Clinically diagnosed late-onset fulminant Wilson’s disease without cirrhosis: A case report

doi:10.3748/wjg.v24.i2.290

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Jan 14, 2018 (publication date) through May 10, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

World J Gastroenterol. Jan 14, 2018; 24(2): 290-296
Published online Jan 14, 2018. doi: 10.3748/wjg.v24.i2.290

Table 1 Laboratory data on admission

Biochemical data		Fe, μg/dL	130
WBC, /μL	26200	ferritin, ng/mL	7817
RBC, ×10⁴/μL	163	IgG, mg/dL	1678
Hb, g/dL	6.1	IgM, mg/dL	86
Platelets, ×10⁴/μL	20.2	IgA, mg/dL	505
MCV, fL	122.7	ANA	< 40
MCH, pg	37.4	AMA-M2, index	2
MCHC, g/dL	30.5	sIL2-R, U/mL	1130
PT, %	19	Direct Coombs	-
PT-INR	2.43	Indirect Coombs	-
D-dimer, μg/mL	1.8	Vitamin B12, pg/mL	> 1500
AST, U/L	164	Folic acid, ng/mL	4
ALT, U/L	15	Erythropoietin, IU/mL	367
LDH, U/L	609	Reticulocytes, %	175
ALP, U/L	26	Viral markers
γGTP, U/L	371	HBsAg, IU/mL	0.02
Alb, g/dL	2.3	HBeAg, S/CO	< 0.5
T-Bil, mg/dL	33.99	HBeAb, %	< 35
D-Bil, mg/dL	25.51	HBcAb, S/CO	0.23
BUN, mg/dL	36	HBsAb, mIU/mL	0
Cr, mg/dL	0.75	HCVAb, S/CO	0.1
UA, mg/dL	2.2	CMV-IgM	0.58
Na, mEq/L	133	CMV-IgG	> 128
K, mEq/L	4.6	EBV-IgM	< 10
T-CHO, mg/dL	83	EBV-IgA	< 10
CRP, mg/dL	2.62	EBV-IgG	80
NH₃, μg/dL	138	HAVAb-IgM, S/CO	< 0.5
Immunological and other data		HAVAb	< 0.4
Fe, μg/dL	130	HSV-CF	< 4
Ferritin, ng/mL	7817

ULN of AST: 10-31 U/L; ULN of ALT: 4-31 U/L; ULN of ALP: 98-328 U/L; ULN of γGTP: 8-45 U/L. Alb: Albumin; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; ANA: Antinuclear antibody; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen; CMV: Cytomegalovirus; Cr: Creatinine; CRP: C-reactive protein; D-Bil: Direct bilirubin; EBV: Epstein-Barr virus; Fe: Iron; γGTP: Gamma-glutamyl transpeptidase; HAVAb: Hepatitis A virus antibody; Hb: Hemoglobin; HBcAb: Hepatitis B core antibody; HBeAg/Ab: Hepatitis B envelope antigen/antibody; HBsAg/Ab: Hepatitis B surface antigen/antibody; HCVAb: Hepatitis C virus antibody; HSV-CF: Herpes simplex virus-complement fixation; IgG/IgA/IgM: Immunoglobulin G/A/M; K: Potassium; LDH: Lactate dehydrogenase; Na: sodium; NH3: Ammonia; PT: Prothrombin time; RBC: Red blood cell; sIL2-R: Soluble interleukin 2-receptor; T-Bil: Total bilirubin; T-CHO: Total cholesterol; UA: Uric acid; ULN: Upper limit of normal; WBC: White blood cell.

Citation: Amano T, Matsubara T, Nishida T, Shimakoshi H, Shimoda A, Sugimoto A, Takahashi K, Mukai K, Yamamoto M, Hayashi S, Nakajima S, Fukui K, Inada M. Clinically diagnosed late-onset fulminant Wilson’s disease without cirrhosis: A case report. World J Gastroenterol 2018; 24(2): 290-296
URL: https://www.wjgnet.com/1007-9327/full/v24/i2/290.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i2.290