INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

doi:10.3748/wjg.v24.i2.195

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Jan 14, 2018 (publication date) through Apr 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2018; 24(2): 195-210
Published online Jan 14, 2018. doi: 10.3748/wjg.v24.i2.195

Table 2 INT-767 and obeticholic acid improve liver histomorphology in ob/ob-NASH steatohepatitis mice with biopsy-confirmed liver pathology

Treatment	Fibrosis stage			NAS
Treatment	No improvement	With improvement	% improving¹	No improvement	With improvement	% improving¹
Vehicle ( = 11)	11	0	0%	11	0	0%
OCA 10 mg/kg ( = 12)	10	2	17%	8	4	33%
OCA 30 mg/kg ( = 11)	7	4	36%^a	0	11	100%^a
INT-767 3.0 mg/kg ( = 12)	12	0	0%	7	5	42%^a
INT-767 10 mg/kg ( = 11)	2	9	82%^a	0	11	100%^a

Subjects (%) achieving >

¹points improvement in score from baseline;

^aP < 0.05 vs vehicle (χ² test).

Citation: Roth JD, Feigh M, Veidal SS, Fensholdt LK, Rigbolt KT, Hansen HH, Chen LC, Petitjean M, Friley W, Vrang N, Jelsing J, Young M. INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis. World J Gastroenterol 2018; 24(2): 195-210
URL: https://www.wjgnet.com/1007-9327/full/v24/i2/195.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i2.195