Copyright ©The Author(s) 2018.
World J Gastroenterol. May 7, 2018; 24(17): 1859-1867
Published online May 7, 2018. doi: 10.3748/wjg.v24.i17.1859
Table 1 Risk factors and predictors of fibrostenosing Crohn’s disease
Clinical[4]Age at diagnosis < 40 yr
Perianal disease at diagnosis
Need for steroids during first flare
Small bowel disease location
Prior appendectomy
Endoscopic[4]Deep mucosal ulcerations
Genetic[4]Nucleotide oligomerisation domain 2 (NOD2) variants
Janus-associated kinase 2 (JAK2)
Caspase-recruitment domain 15 (CARD15)
NOD2/CARD15 mutations on both chromosomes
TNF superfamily 15 (TNFSF15) in Asians
5T5T in the MMP3 gene
Serological[4]Antimicrobial antibodies
anti-Saccharomyces cerevisiae antibodies (ASCA) IgA in Asians