Impact of enhanced recovery after surgery programs on pancreatic surgery: A meta-analysis

Table 3 Results of Subgroup Analysis

Outcomes of interest	Studies	Patients	OR/WMD	95%CI	P-value	Heterogeneity P-value	I2, %
Studies with cases ≥ 100
POPF	14	3067	0.87	0.73-1.03	0.11	0.02	48
DGE	14	3117	0.58	0.47-0.71	< 0.00001	0.07	39
Overall complications	14	3045	0.57	0.45-0.72	< 0.00001	0.006	55
Mild complications	9	1470	0.74	0.59-0.93	0.009	0.06	46
Abdominal infection	10	2087	0.67	0.51-0.87	0.003	0.07	42
PLOS	10	2394	-4.64	-6.37 to -2.91	< 0.00001	0.009	65
Mortality	15	2802	0.83	0.51-1.37	0.47	1	0
Readmission	12	2877	1.05	0.83-1.33	0.68	0.23	22
Unintended reoperation	9	1955	0.85	0.60-1.21	0.38	0.96	0
MINORS score > 12
POPF	15	2784	0.84	0.70-1.00	0.05	0.13	30
DGE	16	2949	0.52	0.42-0.64	< 0.00001	0.12	31
Overall complications	16	3008	0.56	0.44-0.71	< 0.00001	0.01	51
Mild complications	11	1504	0.67	0.54-0.83	0.0003	0.24	21
Abdominal infection	10	1791	0.63	0.46-0.85	0.002	0.05	46
PLOS	11	2272	-4.35	-5.97 to -2.72	< 0.00001	0.003	66
Mortality	16	2523	0.96	0.56-1.65	0.89	0.99	0
Readmission	13	2598	1.09	0.84-1.43	0.52	0.82	0
Unintended reoperation	11	1787	0.96	0.65-1.41	0.83	0.94	0

CI: Confidence interval; DGE: Delayed gastric emptying; MINORS score: Methodological Index for Non-Randomized Studies checklist; OR: Odds ratio; PLOS: Postoperative length of hospital stay; POPF: Postoperative pancreatic fistula; WMD: Weighted mean difference.