Helicobacter pylori infection in subjects negative for high titer serum antibody

Table 3 Performance of endoscopic and histological findings for Helicobacter pylori infection

	Accuracy	Sensitivity	Specificity	PPV	NPV
Endoscopic findings
Kyoto classification of gastritis1	89.7	78.3	92.0	66.7	95.4
Atrophy2	85.3	82.6	85.8	54.3	96.0
Intestinal metaplasia	86.0	39.1	95.6	64.3	88.5
Enlarged folds	85.3	17.4	99.1	80.0	85.5
Nodularity	84.6	8.7	100	100	84.3
Redness	86.8	52.2	93.8	63.2	90.6
Gastric sticky mucus	78.7	34.8	87.6	36.4	86.8
Gastric ulcer	83.8	4.3	100	50.0	83.7
Duodenal ulcer	82.4	4.3	98.2	33.3	83.5
Gastroesophageal reflux disease	71.3	8.7	84.1	10.0	81.9
Hiatal hernia	72.8	8.7	85.8	11.1	82.2
Fundic gland polyp	54.4	4.3	64.6	2.4	76.8
Histological findings
H. pylori density	96.3	78.3	100	100	95.8
Chronic inflammation	80.1	91.3	77.9	45.7	97.8
Neutrophil activity	94.1	65.2	100	100	93.4
Intestinal metaplasia	81.6	4.3	97.3	25.0	83.3
Glandular atrophy	81.6	4.3	97.3	25.0	83.3

¹A score of 2 or more was defined as positive;

²A score of 1 or more was defined as positive. The data are presented as %. Positive urea breath test was defined as H. pylori infection. PPV: Positive predictive value; NPV: Negative predictive value; H. pylori: Helicobacter pylori.