Recurrence in node-negative advanced gastric cancer: Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series

Table 2 Prognostic factors for recurrence in N0 gastric cancer patients

	Group 1 (with recurrence)	Group 2 (no recurrence)	P value3
	(n = 41)	(n = 437)
Gender (male)	28	263	0.308
Age (> 65)	19	201	0.966
Tumor markers1	6/25	27/207	0.138
Tumor location (upper)	7	60	0.555
Tumor size (> 5 cm)	16	132	0.242
Tumor invasion (T)
T2	19	259	0.108
T3	13	168	0.395
T4a	9	10	0.001
Lauren histotype
Intestinal	24	291	0.768
Diffuse	12	69	0.012
Mixed / Unavailable	5	77	0.509
Histological grading (G)
G1	7	80	0.844
G2	22	265	0.382
G3	12	92	0.222
Retrieved nodes2 (mean) > 25	26	273	0.905
Associated resections - yes	8	45	0.772
Major morbidity - yes	8	53	0.175

¹Almost 1 tumor marker positive, including CEA, CA 19.9, or other tumor marker. Only 282 cases were available for analysis;

²This value reflects the exclusion from our analysis of patients with less than 15 retrieved nodes;

³P values of χ² test for gender, tumor markers, tumor location, tumor invasion (T), Lauren histotype, histological grading (G), associated resections, post-operative morbidity. P values of Student t-test for age, tumor size, and the number of retrieved nodes.