Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy

Table 1 Proposed[80] colorectal cancer classification

	MMR	CIMP	BRAF	KRAS
Phipps
Subtype 1	MSI-H	+	+	-
Subtype 2	MSS or MSI-L	+	+	-
Subtype 3	MSS or MSI-L	-	-	+
Subtype 4	MSS or MSI-L	-	-	-
Subtype 5	MSI-H	-	-	-
Sinicrope
Subtype 1	MSI	+	+	+/-
Subtype 2	MSS	+/-	+	-
Subtype 3	MSS	+/-	-	+
Subtype 4	MSS	+/-	-	-
Subtype 5	MSI	-	-	+/-

Based on the classification system proposed by Jass[80], Phipps et al[8] and Sinicrope et al[9] proposed new colorectal cancer (CRC) divisions to better stratify disease based on prognosis. (+): Mutated; (-): Wild-type.