Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Sep 14, 2014; 20(34): 12118-12131
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12118
Table 2 Most important genetic syndromes associated with an increased risk of pancreatic cancer
SyndromeGeneRelative riskRisk at age of 70
Familial pancreatic cancerUnknown
1 or more first degree relative(s)94%
1 first degree relative4.52%
2 first degree relatives6.43%
3 or more first degree relatives3216%
Peutz Jeghers syndromeLKB1/STK1113230%-60%
Hereditary pancreatitisPRSS150-7040%
Familial atypical multiple mole melanomaCDKN2A/p1634-3917%
Breast and ovarian cancer syndromeBRCA1/BRCA22.3-101%-5%
Cystic fibrosisCFTR5.3< 5%
Hereditary non-polyposis colon cancerMSH2, MLH1, MSH6, PMS, PMS24.7< 5%
Familial adenomatous polyposisAPC4.52%