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Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 21, 2014; 20(3): 630-638
Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.630
Figure 3
Figure 3 Effects of Helicobacter pylori gamma-glutamyl transpeptidase on T cell-mediated immunity. Helicobacter pylori gamma-glutamyl transpeptidase (GGT) and VacA inhibit T cell proliferation and differentiation to T helper 1 (TH1) and TH17. They also prevent T cell immunity by reprogramming dendritic cells to produce interleukin-10 (IL-10) and IL-18 and promote the differentiation of naive T cells into T regulatory (Treg) cells that further suppress TH1 and TH17 effector functions. FOXP3: Forkhead box P3; NFAT: Nuclear factor of activated T cells; IFN-γ: Interferon gamma.