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Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 7, 2014; 20(13): 3457-3467
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3457
Table 1 Characterization and the main function of cell surface molecules required for hepatitis C virus entry
CharacterizationMain function in HCV entry
GAGsBinding factorAttachment to HCV E1 and ApoE
LDL-RBinding factorBinding to virion-associated lipoprotein
SR-BIReceptorBinding to virion-associated lipoprotein; lipid transfer; binding to E2 HVR1
CD81ReceptorInteraction with E2; signaling pathway activation which promotes actin remodeling
CLDN1ReceptorInteraction with HCV-CD81 complex
OCLNReceptorFunction at the late stage of HCV entry
EGFR and EphA2Entry factorSignaling pathways activation which lead to the formation of CD81-CLDN1 complexes
TfR1Entry factorPossibly involved in virus internalization
NPC1L1Entry factorPossibly involved in endosomal fusion