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Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 7, 2014; 20(13): 3443-3456
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3443
Table 1 Genes and hepatitis C infection
Lipid metabolism genes altered by HCV
SREBPSterol regulatory element-binding proteinCore protein increases the gene expression[110]
PPARαPeroxisome proliferators-activated receptor alphaHCV infection led to reduction in gene expression[126]
MTPMicrosomal triacylglycerol transfer proteinCore protein led to reduction in MTP activity and lower gene expression[127,128]
PEPCKPhosphoenolpyruvate carboxykinaseNS5A increases gene expression and development of steatosis[129]
FASFatty acid synthaseCore protein induces FAS promoter activity and severity of steatosis[115]
RXRαRetinoid X receptor-alphaCore protein enhances the transcriptional activity and contributes to the pathogenesis of infection[112]
APOEApolipoprotein EHCV forms lipoviroparticles and hijacks ApoE for entry into hepatocyte[48]
Genes associated with spontaneous clearance of HCV
IL28BInterleukin 28Brs12979860 CC[130]
IL28BInterleukin 28Brs8099917 TT[131]
IL28BInterleukin 28Bss469415590DG[132]
KIRNatural killer cell immunoglobulin-like receptorKIR3DS1[133]
TNFαTumor necrosis factor-α-863CC[134]
APOBApolipoprotein Brs934197 TT[135]