Case Report
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 28, 2013; 19(32): 5381-5384
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5381
Table 2 Summary of the cases reported in the literature on hepatotoxicity by glucosamine and/or chondroitin sulfate
Ref.Age (yr) Sex (F/M)DrugconsumedLength of consumptionLatencyJaundicePeak in AST/ALT (IU/L)HypersensitivityHepatic failureFollow-up
Ossendza et al[4]52/MGlucosamine3 wk4 wkYes263/63Pruritus, eosinophiliaNoComplete recovery
Smith et al[5]64/MGlucosamine/chondroitin sulfate4 wk5 wkYes-/1461-YesDeath
57/FGlucosamine4 wk5 wkYes-/1130Pruriginous rashNoChronic hepatitis
55/FGlucosamine6 mo8 moNo-/175-NoComplete recovery
Linnebur et al[6]71/FGlucosamine/chondroitin sulfate7 wk3 wkNo600-700/ 00-500-NoComplete recovery
85/FGlucosamine/chondroitin sulfate3 wk3 wkNo54/37-NoComplete recovery
Authors’ cases71/FGlucosamine1 yrNANo182/282-NoLiver tests return to pretreatment (basal) values
77/FGlucosamine3 moNANo161/162Pruriginous rashNoLiver tests return to (basa) values