Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors

Table 2 Comparison of liver histological findings at the time of liver biopsy in sustained virological response patients, between F0 + 1 + 2 and F3 + 4 groups

Parameter	Score					F0+1+2	F3+4	P value
	0	1	2	3	4
Irregular regeneration
Dysplastic change	109	50	49	21	3	0.769 ± 0.998	1.660 ± 1.081	0.0001
Oncocytes	211	16	4	1	0	0.066 ± 0.290	0.300 ± 0.647	0.0003
Map-like distribution	160	37	22	13	0	0.396 ± 0.756	0.960 ± 1.142	0.0001
Nodular arrangement	216	13	1	2	0	0.027 ± 0.164	0.320 ± 0.713	0.0001
Bulging	206	18	6	2	0	0.104 ± 0.400	0.340 ± 0.688	0.0022
Atypical hepatocytes	227	5	0	0	0	0.005 ± 0.074	0.080 ± 0.274	0.0012
Inflammatory cell infiltration
Peri-portal	0	65	127	35	5	1.819 ± 0.652	2.260 ± 0.828	0.0001
Parenchymal	0	37	149	44	2	1.978 ± 0.585	2.300 ± 0.678	0.0010
Portal lymphocyte	0	5	103	121	3	2.456 ± 0.562	2.780 ± 0.507	0.0003
Portal lymphoid reaction	0	6	47	78	101	3.132 ± 0.850	3.360 ± 0.802	0.0904
Fibrosis
F stage	5	128	49	34	16
Portal sclerosis	113	81	32	6	0	0.615 ± 0.783	1.020 ± 0.795	0.0014
Pericellular fibrosis	89	90	41	11	1	0.802 ± 0.870	1.260 ± 0.853	0.0011
Perivenular fibrosis	63	66	65	25	0	1.236 ± 1.016	1.243 ± 0.895	0.9691
Bridging necrosis Y (presence)						0/228	4/228 (1.7%)	0.0020
Bile duct damage	123	71	26	9	2	0.597 ± 0.861	1.000 ± 0.904	0.0041
Steatosis	96	46	68	18	1	0.944 ± 0.990	1.429 ± 1.118	0.0035

Comparison of liver histological findings in sustained virological response patients according to the F stage (F0 + 1 + 2 and F3 + 4) was performed, and the data are shown. The histological findings demonstrated that there was a higher level of deterioration of the liver in the F3 + 4 group as compared to the F0 + 1 + 2 group; liver fibrosis was more progressive and inflammatory reaction was stronger. The number of patients for each score was compared, then the presence of bridging necrosis (Y/N) was compared and the remaining parameters are presented as mean ± SD. Scoring: score 0, none; score 1, minimal (observed in less than one third of the field); score 2, mild (observed in one third to less than two thirds of the field); score 3, moderate (observed in two thirds or more of the field) and score 4, severe (diffusely in all fields).