Aberrant glycosylation of the anti-Thomsen-Friedenreich glycotope immunoglobulin G in gastric cancer patients

doi:10.3748/wjg.v19.i23.3573

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Jun 21, 2013 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2013; 19(23): 3573-3582
Published online Jun 21, 2013. doi: 10.3748/wjg.v19.i23.3573

Table 2 Anti-TF IgG level and lectin binding profile: Sensitivity and specificity for gastric cancer

Parameter	Sensitivity % (95%CI)	Specificity % (95%CI)	ROC statistics		Sensitivity at specificity 90%
Parameter	Sensitivity % (95%CI)	Specificity % (95%CI)	Area under curve	P value
Anti-TF IgG	65.17 (51.34-76.26)	67.74 (56.66-76.98)	0.70	< 0.0001	Sensitivity at specificity 90%	50.56
ConA	62.92 (48.37-74.49)	56.90 (46.37-67.74)	0.64	0.004	24.72
SNA	78.79 (61.09-91.02)	79.17 (65.01-89.53)	0.87	< 0.0001	57.58
AAL	69.70 (51.29-84.41)	64.58 (49.46-77.84)	0.68	0.006	12.12
ConA/SNA	72.73 (57.21-85.04)	88.64 (71.80-96.60)	0.91	< 0.0001	63.64
AAL/ConA	84.85 (68.10-94.89)	68.18 (52.42-81.39)	0.78	< 0.0001	33.33
AAL/SNA	84.85 (72.24-93.93)	47.92 (30.80-66.46)	0.68	0.006	3.03

ConA: Concanavalin A; AAL: Aleuria aurantia lectin; SNA: Sambucus nigra agglutinin; Anti-TF IgG: Anti-Thomsen-Friedenreich glycotope immunoglobulin G; ROC: Receiver operator characteristic.

Citation: Kodar K, Izotova J, Klaamas K, Sergeyev B, Järvekülg L, Kurtenkov O. Aberrant glycosylation of the anti-Thomsen-Friedenreich glycotope immunoglobulin G in gastric cancer patients. World J Gastroenterol 2013; 19(23): 3573-3582
URL: https://www.wjgnet.com/1007-9327/full/v19/i23/3573.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i23.3573