Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. May 21, 2013; 19(19): 2864-2882
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2864
Table 4 Details of the various causality assessment methods for herb induced liver injury
Assessed items with specific scoresCIOMSMVNaranjoKLAd hocDILINWHOExpert opinion
Time frame of latency period (score)++000000
Time frame of challenge (score)++000000
Time frame of dechallenge (score)++000000
Recurrent ALT or ALP increase (score)+0000000
Definition of risk factors (score)+0000000
Verified alternative diagnoses (score)++000000
Assessed HAV, HBV, HCV (score)++000000
Assessed CMV, EBV, HSV, VZV (score)++000000
Liver and biliary tract imaging (score)+0000000
Liver vessel Doppler sonography (score)+0000000
Assessed preexisting diseases (score)+0000000
Evaluated cardiac hepatopathy (score)+0000000
Excluded alternative diagnoses (score)+++00000
Comedication (score)+0+00000
Prior known herbal hepatotoxicity (score)+++00000
Searched unintended reexposure (score)+++00000
Defined unintended reexposure (score)++000000
Unintended reexposure (score)++000000
Laboratory hepatotoxicity criteria++000+0+
Laboratory hepatotoxicity pattern++000+0+
Liver specific method++000+0+
Structured, liver related method++000+00
Quantitative, liver related method++000000
Validated method for hepatotoxicity++000000