Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 14, 2013; 19(10): 1527-1540
Published online Mar 14, 2013. doi: 10.3748/wjg.v19.i10.1527
Table 1 Results of clinical trials with probiotics in irritable bowel syndrome
Ref.Patients (n)Duration of therapyProbiotic strainsDose (CFU/d)Outcomes
Maupas et al[88]341 moSaccharomyces boulardii9 × 109Improved stool number and consistency
Gade et al[89]541 moParaghurt (Streptococcus faecium)1 × 10¹²Improved symptoms
Halpern et al[90]184 moLactobacillus acidophilus2 × 1010Improved symptoms
O’Sullivan et al[91]251 moLactobacillus GG1 × 1010No benefit
Nobaek et al[92]601 moLactobacillus plantarum 299V Pro-Viva®5 × 107Improved global symptoms
Niedzielin et al[93]401 moLactobacillus plantarum 299V Pro-Viva®2 × 1010Improved global symptoms
Kim et al[94]252 d-IBSVSL3®9 × 10¹¹Reduced bloating
Tsuchiya et al[95]683 moLactobacillus acidophilus1.5 × 106Improved symptoms
Lactobacillus helveticus1.3 × 109
Bifidobacterium4.95 × 109
O’Mahony et al[96]802 moBifidobacterium longum subspecies infantis vs Lactobacillus salivarius1 × 1010B. infantis: improved global symptoms and anti-inflammatory cytokine profileLactobacillus salivarius: no benefit
Kajander et al[97]1036 moMixture (2 strains of Lactobacillus rhamnosus, Bifidobacterium breve, Propionibacterium freudenreichii)8-9 × 109Improved global symptoms
Bittner et al[98]250.5 mo29 bacteria + prebiotic Prescript-Assist®2.6 × 108Improved wellbeing
Sen et al[99]121 moLactobacillus plantarum 299V Pro-Viva®5 × 107No benefit; Study design flawed
Bausserman et al[100]501.5 moLactobacillus GG2 × 1010No benefit
Niv et al[101]396 moLactobacillus GG2 × 108No benefit Francis severity IBS score
Kim et al[102]481 or 2 moVSL3®8 × 109Reduced flatulence, retarded colonic transit
Whorwell et al[103]3621 moBifidobacterium longum subspecies infantis 35 624 in 3 doses1 × 106Improved global symptoms
1 × 108
1 × 1010
Long et al[104]600.5 moBifidobacterium2 × 108Symptoms resolved
Gawrońska et al[105]1041 moLactobacillus GG6 × 109Reduced frequency of pain
Moon et al[106]341 moBifidobacterium subtilis, Streptococcus faecium750 mL/d, CFU/d not givenReduced frequency pain
Marteau et al[107]1161 moLactibiane® (4 strains of Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus lactis, Streptococcus thermophilus)1 × 1010Reduced painIncreased colonic transit in those with constipation
Simrén et al[108]761.5 moLactobacillus plantarum 299V2 × 109No benefit
Simrén et al[109]1182 moLactobacillus paracasei ssp paracasei2 × 1010No benefit
Guyonnet et al[110]2741.5 moBifidobacterium animalis, Streptococcus thermophilus and Lactobacillus bulgaricus1.25 × 1010 1.2 × 109Improved bloating and constipation
Drouault-Holowacz et al[111]1161 moBifidobacterium longum, Lactobacillus acidophilus, Lactobacillus lactis, Streptococcus thermophilus1 × 1010Not significant in relieving symptoms
Sinn et al[112]401 moLactobacillus acidophilus2 × 108Improved abdominal pain and discomfort
Enck et al[113]2971 moEscherichia coli, Enterococcus faecalis4.5 × 102Improvement in pain
Hun et al[114]442 moBacillus coagulans8 × 108Improvement abdominal pain and bloating
Dolin et al[115]612 moBacillus coagulans2 × 109Diminution of diarrhea
Ligaarden et al[116]161 moLactobacillus plantarum1010/LWorsening of symptoms
Moayyedi et al[117]19 randomised controlled trials in 1650 patientsProbiotics appear to be efficacious but the magnitude of benefit and the most effective strains are uncertain