Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 14, 2012; 18(42): 6036-6059
Published online Nov 14, 2012. doi: 10.3748/wjg.v18.i42.6036
Table 5 The most important factors contributing to the development of celiac disease[86] (printed with permission)
Factors contributing to the onset of celiac diseaseMechanism
GlutenElicit T cell responses
Induces cytokine production and intestinal lesion
Age of introduction of glutenWeak gut immune during early childhood
HLA-DQ2 or HLA-DQ8Gluten presentation
MYO9BoIncreased permeability of the intestine
Pro-autoimmune genetic backgroundShift in Th1/Th2 balance towards Th1
Viral infectionsDefect in generation of active tolerance (e.g., regulatory T cells)
IFN production
Tissue damageTissue damage
Increased level of tTG
Danger signals
Early termination of breastfeedingDecreased protection against infections
GenderHormone-related pro-autoimmune status