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Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Jun 14, 2012; 18(22): 2745-2755
Published online Jun 14, 2012. doi: 10.3748/wjg.v18.i22.2745
Figure 1
Figure 1 A model of DNA mismatch repair and molecular pathways for microsatellite instability+ colorectal cancers. A: A model of the proposed mechanism of mismatch repair (MMR) proteins, illustrating patterns of relevant heterodimerization; B: The models for colorectal cancer (CRC) carcinogenesis are presented in parallel for Lynch syndrome and sporadic cases. HNPCC: Hereditary nonpolyposis colorectal cancer; MSI: Microsatellite instability; CIMP: CpG island methylator phenotype; MSI: Microsatellite instability.