Brief Article
Copyright ©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 28, 2011; 17(4): 506-513
Published online Jan 28, 2011. doi: 10.3748/wjg.v17.i4.506
Figure 1
Figure 1 Schematic representation of intracellular pathways involved in 2-CdA cytotoxicity. (Adapted with permission from Borak, 2006). 2-CdA-MP: Cladribine monophosphate; 2-CdA-DP: Cladribine diphosphate; 2-CdA-TP: Cladribine triphosphate; dCK: Deoxycytidine kinase; 5’-NT: 5’-nucleotidase; hENT: Human equilibrative nucleoside transporter; hCNT: Human concentrative nucleoside transporter; AIF: Apoptosis inducing factor; APAF-1: Apoptotic protease activating factor; PARP: Poly (ADP-ribose) polymerase.