Original Article
Copyright ©2011 Baishideng Publishing Group Co.
World J Gastroenterol. May 14, 2011; 17(18): 2315-2325
Published online May 14, 2011. doi: 10.3748/wjg.v17.i18.2315
Figure 1
Figure 1 (-)-Epigallocatechin-3-gallate inhibits vascular endothelial growth factor production induced by interleukin-6 in human gastric cancer cells. A: When treated with (-)-Epigallocatechin-3-gallate (EGCG), vascular endothelial growth factor (VEGF) expression was dose-dependently decreased; B: Enzyme-linked immunosorbent assay showed that interleukin-6 (IL-6) induced VEGF secretion in human gastric cancer (AGS) cells and a 2.8-fold increase was observed. EGCG treatment dose-dependently reduced VEGF protein level in the conditioned medium. C: IL-6 also induced VEGF mRNA expression and a 3.1-fold increase in VEGF mRNA expression was observed. When treated with EGCG, VEGF mRNA expression was dose-dependently decreased. Values are expressed as percent of control (means ± SE, n = 3, aP < 0.05, bP < 0.01).