Copyright ©2011 Baishideng Publishing Group Co.
World J Gastroenterol. May 14, 2011; 17(18): 2288-2301
Published online May 14, 2011. doi: 10.3748/wjg.v17.i18.2288
Table 8 Other effects of silybin on cellular signaling[106-122]
Induction of apoptosis through an inhibition of IGF-IR
Down regulation of survivin and an increase in p53 expression
Block of cycle-regulator cyclins and promoter activities
Decrease of MMP-1 production
Decrease of angiogenesis
Inhibition of VEGF expression
Inhibition of HIF-1α
Increase of IGFBP-3