Silybin and the liver: From basic research to clinical practice

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May 14, 2011 (publication date) through Dec 10, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2011; 17(18): 2288-2301
Published online May 14, 2011. doi: 10.3748/wjg.v17.i18.2288

Table 5 Antioxidant effects of silybin[65-75]

Doses	Cells	Targets
From 10 to 100 μmol/L	Hepatocytes	Decreased formation of reactive oxygen species from mitochondria; iron chelator
From 10 to 100 μmol/L	HepG2	Decreased formation of superoxide anion
Mean dose with documented effects: 20 μmol/L	Kupffer cells	Decrease of NO production
	Monocytes	Scavenger of lipodienyl, methyl, trichloromethyl radicals
	Endothelial cells	Decrease of hydrogen peroxide concentration
	Cancer cells	Block of membrane lipid peroxidation

Citation: Loguercio C, Festi D. Silybin and the liver: From basic research to clinical practice. World J Gastroenterol 2011; 17(18): 2288-2301
URL: https://www.wjgnet.com/1007-9327/full/v17/i18/2288.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i18.2288