Copyright ©2011 Baishideng Publishing Group Co.
World J Gastroenterol. May 14, 2011; 17(18): 2288-2301
Published online May 14, 2011. doi: 10.3748/wjg.v17.i18.2288
Table 5 Antioxidant effects of silybin[65-75]
From 10 to 100 μmol/LHepatocytesDecreased formation of reactive oxygen species from mitochondria; iron chelator
HepG2Decreased formation of superoxide anion
Mean dose with documented effects: 20 μmol/LKupffer cellsDecrease of NO production
MonocytesScavenger of lipodienyl, methyl, trichloromethyl radicals
Endothelial cellsDecrease of hydrogen peroxide concentration
Cancer cellsBlock of membrane lipid peroxidation