Copyright ©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 28, 2011; 17(12): 1519-1528
Published online Mar 28, 2011. doi: 10.3748/wjg.v17.i12.1519
Table 2 Possible therapeutic indications of butyrate in gastroenterology
FunctionsTherapeutic indicationsPotential applications
Regulation of fluid and electrolyte uptakeAcute gastroenteritis[9,10]Irritable bowel syndrome[80]
Cholera[7,8]Aspecific chronic diarrhea[4]
Congenital chloride diarrhea[11,12]Traveler’s diarrhea[4]
Antibiotic associated diarrhea[4,20]
Chronic secretory diarrhea[4]
Cystic fibrosis[14,19]
Mucosal atrophy in malnutrition[101]
Effects on proliferation and differentiation of epithelial intestinal cellsAcute gastroenteritis[9,10]Mucosal atrophy in total parenteral nutrition[101,102]
IBD[53-65]Mucosal atrophy in radiotherapy or chemotherapy[101]
Short bowel syndrome and intestinal failure[103]
Prevention of colorectal cancer[46]
Intestinal polyposis[104]
Anti-inflammatory effectIBD[53-65]Pouchitis[105]
Allergic colitis[106]