Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage?

Table 2 Liver-related hepatotoxicity induced by non-steroidal anti-inflammatory drugs

Drug	Pattern of liver damage	Proposed mechanism	Incidence
Aspirin	Acute and chronic hepatitis	Dose dependent	Low
	Reye’s syndrome	> with high dose
Diclofenac	Acute and chronic hepatitis	Metabolic	Low
	Mixed damage and pure cholestasis	Immunologic
Sulindac	Acute hepatitis and mixed injury	Hypersensivity	Moderate
Ibuprofen	Acute hepatitis, ductopenia	Metabolic	Low
Naproxen	Cholestatic, mixed damage	Metabolic	Low
Coxibs	Acute hepatitis, mixed damage	Probably metabolic	Low
Oxicams	Acute hepatitis, massive and submassive necrosis, cholestasis and ductopenia	Metabolic	Low
Nimesulide	Acute hepatitis, pure cholestasis	Probably metabolic	Moderate