Haemodynamic and renal effects of tadalafil in patients with cirrhosis

Table 1 Effects of tadalafil on portal and systemic haemodynamics and renal function in patients with cirrhosis (mean ± SE)

	Compensated (n = 6)		P1	Decompensated (n = 6)		P1	P2
	Baseline	2 h		Baseline	2 h
PVV (m/s)	0.103 ± 0.016	0.102 ± 0.019	0.9	0.186 ± 0.011	0.18 ± 0.015	0.8	0.6
PFV (L/min)	0.611 ± 0.116	0.543 ± 0.125	0.2	1.194 ± 0.169	1.175 ± 0.198	0.7	0.5
MAP (mmHg)	93.9 ± 3	87.5 ± 2.9	0.02	84.8 ± 2.4	76.9 ± 2	0.001	0.02
CO (L/min)	5.56 ± 0.23	5.7 ± 0.24	0.04	6.91 ± 0.3	7.35 ± 0.25	0.002	0.03
SVR (dynes.sec.cm-5)	1708 ± 116	1555 ± 101	0.02	1243 ± 84	1056 ± 59	0.001	0.03
ClCre (mL/min)	98.6 ± 8.1	95.6 ± 7.4	0.09	71.6 ± 2.4	64 ± 2.8	0.001	0.01
UNaV (μmol/min)	102 ± 15.9	97 ± 13.7	0.09	29.6 ± 7.3	20.6 ± 4.6	0.02	0.01

¹vs baseline values; ²vs basal and final results in two groups of patients. PVV: Portal vein velocity; PFV: Portal flow volume; MAP: Mean arterial pressure; CO: Cardiac output; SVR: Systemic vascular resistance; ClCre: Creatinine clearance; UNaV: Urinary sodium.